P245 The Relationship Between the Endoscopic Healing Index and Magnetic Resonance Enterography In Crohn’s Disease Patients

Abstract Background The endoscopic healing index (EHI) is a serum biomarker panel that identifies Crohn’s Disease (CD) activity. Endoscopy and biomarkers are limited in assessing small bowel disease compared to magnetic resonance enterography (MRE). Simplified Magnetic Resonance Index of Activity (MaRIAs) validated detect CD Data lacking on the relationship between EHI with other endpoints. This study performed first assessment diagnose CD-related intestinal inflammation MRE using MaRIAs score. Methods were extracted patients within 90 days MRE. We assessed diagnostic accuracy for any (MaRIAs≥1) or severe (MaRIAs≥2) MR identified area under receiver operator characteristic (AUROC) curve analyses. Proportions groups above below FCAL threshold. Analyses repeated active endoscopy (SES-CD≥5), fecal calprotectin (FCAL>50, >250), clinical symptoms (CD PRO-2≥8). Results 241 MREs uniquely paired either from 155 patients, mean age was 42 years, 50.3% female, 83.2% had involvement, 29.7% penetrating disease. time 28 days, 24 days. Both similar (AUROC: EHI:0.635-0.651, FCAL:0.680-0.708). Optimal values 26 endoscopy, respectively. Patients EHI≥42 (100% vs. 63%, p=0.002), FCAL>50µg/g (87% 64%, p<0.001) FCAL>250µg/g (90% 75%, p=0.02) higher rates MaRIAs≥1 lower values. differentiated ileitis more than (delta: 24-25% 11-21%). low high (59-69%) disease, whereas those rarely (6%) FCAL≥50µg/g FCAL<50µg/g (75% 47%, smaller differentiation existed EHI. In PRO-2 scores, remission not associated activity corresponding EHI, Conclusion predominantly ileal EHI>42 FCAL>50 both specific confirm Lower (<42), but (<50), radiologic inflammation. frequently present presence proportions false negative results. However, absence only